Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.


Journal Article

We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis.

Full Text

Cited Authors

  • McCarthy, LC; Hosford, DA; Riley, JH; Bird, MI; White, NJ; Hewett, DR; Peroutka, SJ; Griffiths, LR; Boyd, PR; Lea, RA; Bhatti, SM; Hosking, LK; Hood, CM; Jones, KW; Handley, AR; Rallan, R; Lewis, KF; Yeo, AJ; Williams, PM; Priest, RC; Khan, P; Donnelly, C; Lumsden, SM; O'Sullivan, J; See, CG; Smart, DH; Shaw-Hawkins, S; Patel, J; Langrish, TC; Feniuk, W; Knowles, RG; Thomas, M; Libri, V; Montgomery, DS; Manasco, PK; Xu, CF; Dykes, C; Humphrey, PP; Roses, AD; Purvis, IJ

Published Date

  • December 2001

Published In

Volume / Issue

  • 78 / 3

Start / End Page

  • 135 - 149

PubMed ID

  • 11735220

Pubmed Central ID

  • 11735220

Electronic International Standard Serial Number (EISSN)

  • 1089-8646

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.2001.6647


  • eng