Genetic variations in HLA-B region and hypersensitivity reactions to abacavir.


Journal Article

Hypersensitivity to abacavir affects about 4% of patients who receive the drug for HIV-1 infection. We did a retrospective, case-control study to identify multiple markers in the vicinity of HLA-B associated with hypersensitivity reactions. HLA-B57 was present in 39 (46%) of 84 patients versus four (4%) of 113 controls (p<0 small middle dot0001). However, because of low numbers of women and other ethnic groups enrolled, these findings relate largely to white men. The lower sensitivity of HLA-B57 for predicting hypersensitivity to abacavir identified in this study compared with a previous report highlights that predictive values for markers will vary across populations. Clinical monitoring and management of hypersensitivity reactions among patients receiving abacavir must remain unchanged.

Full Text

Cited Authors

  • Hetherington, S; Hughes, AR; Mosteller, M; Shortino, D; Baker, KL; Spreen, W; Lai, E; Davies, K; Handley, A; Dow, DJ; Fling, ME; Stocum, M; Bowman, C; Thurmond, LM; Roses, AD

Published Date

  • March 2002

Published In

Volume / Issue

  • 359 / 9312

Start / End Page

  • 1121 - 1122

PubMed ID

  • 11943262

Pubmed Central ID

  • 11943262

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/s0140-6736(02)08158-8


  • eng