Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.
Publication
, Journal Article
Scott, WK; Saunders, AM; Gaskell, PC; Locke, PA; Growdon, JH; Farrer, LA; Auerbach, SA; Roses, AD; Haines, JL; Pericak-Vance, MA
Published in: Ann Neurol
September 1997
We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD.
Duke Scholars
Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
September 1997
Volume
42
Issue
3
Start / End Page
376 / 378
Location
United States
Related Subject Headings
- Risk Factors
- Neurology & Neurosurgery
- Middle Aged
- Male
- Humans
- Genotype
- Female
- Apolipoproteins E
- Alzheimer Disease
- Alleles
Citation
APA
Chicago
ICMJE
MLA
NLM
Scott, W. K., Saunders, A. M., Gaskell, P. C., Locke, P. A., Growdon, J. H., Farrer, L. A., … Pericak-Vance, M. A. (1997). Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease. Ann Neurol, 42(3), 376–378. https://doi.org/10.1002/ana.410420317
Scott, W. K., A. M. Saunders, P. C. Gaskell, P. A. Locke, J. H. Growdon, L. A. Farrer, S. A. Auerbach, A. D. Roses, J. L. Haines, and M. A. Pericak-Vance. “Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.” Ann Neurol 42, no. 3 (September 1997): 376–78. https://doi.org/10.1002/ana.410420317.
Scott WK, Saunders AM, Gaskell PC, Locke PA, Growdon JH, Farrer LA, et al. Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease. Ann Neurol. 1997 Sep;42(3):376–8.
Scott, W. K., et al. “Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.” Ann Neurol, vol. 42, no. 3, Sept. 1997, pp. 376–78. Pubmed, doi:10.1002/ana.410420317.
Scott WK, Saunders AM, Gaskell PC, Locke PA, Growdon JH, Farrer LA, Auerbach SA, Roses AD, Haines JL, Pericak-Vance MA. Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease. Ann Neurol. 1997 Sep;42(3):376–378.
Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
September 1997
Volume
42
Issue
3
Start / End Page
376 / 378
Location
United States
Related Subject Headings
- Risk Factors
- Neurology & Neurosurgery
- Middle Aged
- Male
- Humans
- Genotype
- Female
- Apolipoproteins E
- Alzheimer Disease
- Alleles