Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.


Journal Article

We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD.

Full Text

Duke Authors

Cited Authors

  • Scott, WK; Saunders, AM; Gaskell, PC; Locke, PA; Growdon, JH; Farrer, LA; Auerbach, SA; Roses, AD; Haines, JL; Pericak-Vance, MA

Published Date

  • September 1997

Published In

Volume / Issue

  • 42 / 3

Start / End Page

  • 376 - 378

PubMed ID

  • 9307262

Pubmed Central ID

  • 9307262

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.410420317


  • eng

Conference Location

  • United States