Linkage studies in Charcot-Marie-Tooth disease type 2: evidence that CMT types 1 and 2 are distinct genetic entities.

Published

Journal Article

Charcot-Marie-Tooth disease (CMT), the most common inherited peripheral neuropathy, is a progressive sensorimotor neuropathy divided into types 1 and 2 based upon electrophysiologic and neuropathologic differences. The more common autosomal dominant form of CMT type 1 (hereditary motor and sensory neuropathy type I) is genetically heterogeneous, with genes located on chromosomes 1 (type 1B) or 17 (type 1A). However, no locus for CMT type 2 is known. We have performed linkage studies on three large multigenerational CMT type 2 families using probes from chromosome 1 and chromosome 17, which span their respective linkage regions. Multipoint analysis of the chromosome 17 markers excluded linkage over an area of 45 cM--15 cM proximal and 30 cM distal to the region containing CMT type 1A. Multipoint analysis of the chromosome 1 markers exclude linkage 15 cM proximal and 20 cM distal to FC-gamma-RII in the region of CMT 1B. These data indicate that CMT type 2 is genetically distinct from CMT type 1.

Full Text

Duke Authors

Cited Authors

  • Loprest, LJ; Pericak-Vance, MA; Stajich, J; Gaskell, PC; Lucas, AM; Lennon, F; Yamaoka, LH; Roses, AD; Vance, JM

Published Date

  • March 1992

Published In

Volume / Issue

  • 42 / 3 Pt 1

Start / End Page

  • 597 - 601

PubMed ID

  • 1549221

Pubmed Central ID

  • 1549221

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.42.3.597

Language

  • eng

Conference Location

  • United States