Disease-specific target selection: a critical first step down the right road.


Journal Article (Review)

Relevance of a drug target for a disease is often inferred with strong belief but fragile evidence. Here, a program for early identification of human disease-specific drug targets using high-throughput genetic associations is described. Large numbers of well-characterized patients (>1000) and matched controls are screened for genetic associations using several thousand (>7000) single nucleotide polymorphisms from more than 1500 genes. The genes were selected because they are members of target classes for which there are precedents for high-throughput chemical screening technology. This review summarizes the methods and intensive data analyses leading to target gene identification for type 2 diabetes mellitus, including the statistical permutation methodology used to correct for many variables.

Full Text

Cited Authors

  • Roses, AD; Burns, DK; Chissoe, S; Middleton, L; St Jean, P

Published Date

  • February 2005

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 177 - 189

PubMed ID

  • 15708532

Pubmed Central ID

  • 15708532

Electronic International Standard Serial Number (EISSN)

  • 1878-5832

International Standard Serial Number (ISSN)

  • 1359-6446

Digital Object Identifier (DOI)

  • 10.1016/s1359-6446(04)03321-5


  • eng