Genetic linkage analysis of nerve growth factor (beta) in familial Alzheimer's disease.

Journal Article (Journal Article)

Recent studies have not shown linkage of late-onset (mean age, greater than 60 years) familial Alzheimer's disease (FAD) to the chromosome 21 locus reported linked to early-onset FAD. Beta nerve growth factor (beta-NGF) has been considered a candidate gene in the pathogenesis and therapy of FAD, based on its localization in the cortex and hippocampus and its ability to enhance the growth and survival of cholinergic neurons. A 1.5-kb fragment of the beta-NGF gene was used to detect a BglII restriction fragment length polymorphism, which was then used for linkage analysis. A total of 30 families (27 late onset) with 147 affected members were studied. Close linkage (theta less than or equal to 0.03, z less than or equal to -2.00) of late-onset FAD with beta-NGF was excluded. Two apparent obligate crossovers between affected members were detected in different autopsy-confirmed families. Based on these results, beta-NGF is not the gene responsible for late-onset FAD in the families analyzed.

Full Text

Duke Authors

Cited Authors

  • Alberts, MJ; Pericak-Vance, MA; Royal, V; Bebout, J; Gaskell, P; Thomas, J; Hung, WY; Clark, C; Earl, N; Roses, AD

Published Date

  • August 1991

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 216 - 219

PubMed ID

  • 1680304

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.410300217


  • eng

Conference Location

  • United States