Analysis of association at single nucleotide polymorphisms in the APOE region.

Journal Article (Journal Article)

The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE.

Full Text

Duke Authors

Cited Authors

  • Martin, ER; Gilbert, JR; Lai, EH; Riley, J; Rogala, AR; Slotterbeck, BD; Sipe, CA; Grubber, JM; Warren, LL; Conneally, PM; Saunders, AM; Schmechel, DE; Purvis, I; Pericak-Vance, MA; Roses, AD; Vance, JM

Published Date

  • January 1, 2000

Published In

Volume / Issue

  • 63 / 1

Start / End Page

  • 7 - 12

PubMed ID

  • 10662539

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1999.6057


  • eng

Conference Location

  • United States