Pharmacogenetics in drug discovery and development: a translational perspective.


Journal Article (Review)

The ability to predict a patient's drug response on the basis of their genetic information is expected to decrease attrition during the development of new, innovative drugs, and reduce adverse events by being able to predict individual patients at risk. Most pharmacogenetic investigations have focused on drug-metabolism genes or candidate genes that are thought to be involved in specific diseases. However, robust new genetic tools now enable researchers to carry out multi-candidate gene-association and genome-wide studies for target discovery and drug development. Despite the expanding role of pharmacogenetics in industry, however, there is a paucity of published data. New forms of effective and efficient collaboration between industry and academia that may enhance the systematic collection of pharmacogenetic data are necessary to establish genetic profiles related to drug response, confirm pharmacogenetic associations and expedite the development of new drugs and diagnostic tests.

Full Text

Cited Authors

  • Roses, AD

Published Date

  • October 2008

Published In

Volume / Issue

  • 7 / 10

Start / End Page

  • 807 - 817

PubMed ID

  • 18806753

Pubmed Central ID

  • 18806753

Electronic International Standard Serial Number (EISSN)

  • 1474-1784

International Standard Serial Number (ISSN)

  • 1474-1776

Digital Object Identifier (DOI)

  • 10.1038/nrd2593


  • eng