Linkage of Tunisian autosomal recessive Duchenne-like muscular dystrophy to the pericentromeric region of chromosome 13q.

Journal Article (Journal Article)

Autosomal recessive Duchenne-like muscular dystrophy (DLMD) is a severe dystrophic myopathy. The incidence is unknown because of its clinical similarity to Duchenne muscular dystrophy (DMD). Three highly inbred DLMD families from Tunisia were analysed for chromosomal linkage using 135 polymorphic microsatellite markers. A significant lod score of z = 9.15 at theta = 0.03 was found with the 13q12 locus D13S115. Two additional 13q12 markers, D13S143 and D13S120, also gave significant lod scores. Therefore, the primary DLMD defect gene lies in the pericentrometric region of chromosome 13q.

Full Text

Duke Authors

Cited Authors

  • Ben Othmane, K; Ben Hamida, M; Pericak-Vance, MA; Ben Hamida, C; Blel, S; Carter, SC; Bowcock, AM; Petruhkin, K; Gilliam, TC; Roses, AD

Published Date

  • December 1992

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 315 - 317

PubMed ID

  • 1303286

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng1292-315

Language

  • eng

Conference Location

  • United States