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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.

Publication ,  Journal Article
Corder, EH; Saunders, AM; Strittmatter, WJ; Schmechel, DE; Gaskell, PC; Small, GW; Roses, AD; Haines, JL; Pericak-Vance, MA
Published in: Science
August 13, 1993

The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

August 13, 1993

Volume

261

Issue

5123

Start / End Page

921 / 923

Location

United States

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Male
  • Linkage Disequilibrium
  • Humans
  • Homozygote
  • Genotype
  • General Science & Technology
  • Gene Frequency
  • Female
 

Citation

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Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., … Pericak-Vance, M. A. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261(5123), 921–923. https://doi.org/10.1126/science.8346443
Corder, E. H., A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell, G. W. Small, A. D. Roses, J. L. Haines, and M. A. Pericak-Vance. “Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.Science 261, no. 5123 (August 13, 1993): 921–23. https://doi.org/10.1126/science.8346443.
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921–3.
Corder, E. H., et al. “Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.Science, vol. 261, no. 5123, Aug. 1993, pp. 921–23. Pubmed, doi:10.1126/science.8346443.
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921–923.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

August 13, 1993

Volume

261

Issue

5123

Start / End Page

921 / 923

Location

United States

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Male
  • Linkage Disequilibrium
  • Humans
  • Homozygote
  • Genotype
  • General Science & Technology
  • Gene Frequency
  • Female