Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
Journal Article (Journal Article)
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
Full Text
Duke Authors
Cited Authors
- Corder, EH; Saunders, AM; Strittmatter, WJ; Schmechel, DE; Gaskell, PC; Small, GW; Roses, AD; Haines, JL; Pericak-Vance, MA
Published Date
- August 13, 1993
Published In
Volume / Issue
- 261 / 5123
Start / End Page
- 921 - 923
PubMed ID
- 8346443
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.8346443
Language
- eng
Conference Location
- United States