Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
Corder, EH; Saunders, AM; Strittmatter, WJ; Schmechel, DE; Gaskell, PC; Small, GW; Roses, AD; Haines, JL; Pericak-Vance, MA
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