Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism.

Journal Article (Journal Article)

The non-Abeta component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/alpha-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.

Full Text

Duke Authors

Cited Authors

  • Xia, Y; Rohan de Silva, HA; Rosi, BL; Yamaoka, LH; Rimmler, JB; Pericak-Vance, MA; Roses, AD; Chen, X; Masliah, E; DeTeresa, R; Iwai, A; Sundsmo, M; Thomas, RG; Hofstetter, CR; Gregory, E; Hansen, LA; Katzman, R; Thal, LJ; Saitoh, T

Published Date

  • August 1996

Published In

Volume / Issue

  • 40 / 2

Start / End Page

  • 207 - 215

PubMed ID

  • 8773602

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.410400212


  • eng

Conference Location

  • United States