Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism.
The non-Abeta component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/alpha-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.
Duke Scholars
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- Transcription, Genetic
- Synucleins
- Protein Precursors
- Polymorphism, Genetic
- Point Mutation
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Molecular Sequence Data
- Immunohistochemistry
- Humans
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Transcription, Genetic
- Synucleins
- Protein Precursors
- Polymorphism, Genetic
- Point Mutation
- Neurology & Neurosurgery
- Nerve Tissue Proteins
- Molecular Sequence Data
- Immunohistochemistry
- Humans