Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations.


Journal Article

Endothelin-1 (EDN1) has been reported to be implicated in the pathophysiology of asthma. Literature results on the genetic association of EDN1 in asthma are inconsistent. Eleven single nucleotide polymorphisms in EDN1 were genotyped in 342 and 100 families from UK and Norway, respectively. Asthma, bronchial hyperreactivity (BHR) and atopic asthma phenotypes were analyzed for the family-based association. Five single nucleotide polymorphisms (SNPs) were associated with asthma (0.0017

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Cited Authors

  • Zhu, G; Carlsen, K; Carlsen, K-H; Lenney, W; Silverman, M; Whyte, MK; Hosking, L; Helms, P; Roses, AD; Hay, DW; Barnes, MR; Anderson, WH; Pillai, SG

Published Date

  • January 2008

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 23 - 29

PubMed ID

  • 17960156

Pubmed Central ID

  • 17960156

Electronic International Standard Serial Number (EISSN)

  • 1476-5470

International Standard Serial Number (ISSN)

  • 1466-4879

Digital Object Identifier (DOI)

  • 10.1038/sj.gene.6364441


  • eng