The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease.

Journal Article (Journal Article)

Previous studies have reported conflicting results regarding the association of the Q7R polymorphism in the Saitohin gene with late-onset Alzheimer disease (AD). Given that AD is a tauopathy but no mutations or polymorphisms in Tau have been consistently associated with AD, and that Saitohin is nested in intron 9 of Tau and shares a similar expression pattern, we tested this association in 690 multiplex AD families and in a case-control sample (903 patients and 320 controls). We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association.

Full Text

Duke Authors

Cited Authors

  • Oliveira, SA; Martin, ER; Scott, WK; Nicodemus, KK; Small, GW; Schmechel, DE; Doraiswamy, PM; Roses, AD; Saunders, AM; Gilbert, JR; Haines, JL; Vance, JM; Pericak-Vance, MA

Published Date

  • August 28, 2003

Published In

Volume / Issue

  • 347 / 3

Start / End Page

  • 143 - 146

PubMed ID

  • 12875906

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(03)00670-0


  • eng

Conference Location

  • Ireland