Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Journal Article (Journal Article)

Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a neuropathological feature of Alzheimer disease (AD). We examined the possibility that commonly observed variability in A beta deposition in late-onset AD might be related to apolipoprotein E genotype (APOE gene; the two most common alleles are 3 and 4), since APOE4 is a susceptibility gene for late-onset AD and apolipoprotein E interacts strongly with A beta in vitro. In an autopsy series of brains of late-onset AD patients, we found a strong association of APOE4 allele with increased vascular and plaque A beta deposits. Late-onset AD patients with one or two APOE4 alleles have a distinct neuropathological phenotype compared with patients homozygous for APOE3.

Full Text

Duke Authors

Cited Authors

  • Schmechel, DE; Saunders, AM; Strittmatter, WJ; Crain, BJ; Hulette, CM; Joo, SH; Pericak-Vance, MA; Goldgaber, D; Roses, AD

Published Date

  • October 15, 1993

Published In

Volume / Issue

  • 90 / 20

Start / End Page

  • 9649 - 9653

PubMed ID

  • 8415756

Pubmed Central ID

  • PMC47627

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.90.20.9649


  • eng

Conference Location

  • United States