The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2.

Published

Journal Article

Sensitivity to nonmodified poliovirus infection is an autosomal dominant trait, specific to primates. The gene for poliovirus sensitivity (PVS) is encoded on human chromosome 19. In order to sublocalize the PVS gene, we infected rodent-human hybrid cell lines that divide human chromosome 19 into four regions with poliovirus 1 and/or 3. When infected, these hybrid cell lines showed the typical cytopathic effect of poliovirus infection only if they contained 19q12----q13.2 as the smallest region of overlap. Appropriate negative and positive controls were used. PVS may be of relevance to myotonic dystrophy (DM) and the inherited motor neuron diseases: to DM because it localizes to the same region of chromosome 19 and to the inherited motor neuron diseases because it encodes a cell-surface receptor expressed on motor neurons.

Full Text

Duke Authors

Cited Authors

  • Siddique, T; McKinney, R; Hung, WY; Bartlett, RJ; Bruns, G; Mohandas, TK; Ropers, HH; Wilfert, C; Roses, AD

Published Date

  • August 1988

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 156 - 160

PubMed ID

  • 2852161

Pubmed Central ID

  • 2852161

International Standard Serial Number (ISSN)

  • 0888-7543

Language

  • eng

Conference Location

  • United States