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The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2.

Publication ,  Journal Article
Siddique, T; McKinney, R; Hung, WY; Bartlett, RJ; Bruns, G; Mohandas, TK; Ropers, HH; Wilfert, C; Roses, AD
Published in: Genomics
August 1988

Sensitivity to nonmodified poliovirus infection is an autosomal dominant trait, specific to primates. The gene for poliovirus sensitivity (PVS) is encoded on human chromosome 19. In order to sublocalize the PVS gene, we infected rodent-human hybrid cell lines that divide human chromosome 19 into four regions with poliovirus 1 and/or 3. When infected, these hybrid cell lines showed the typical cytopathic effect of poliovirus infection only if they contained 19q12----q13.2 as the smallest region of overlap. Appropriate negative and positive controls were used. PVS may be of relevance to myotonic dystrophy (DM) and the inherited motor neuron diseases: to DM because it localizes to the same region of chromosome 19 and to the inherited motor neuron diseases because it encodes a cell-surface receptor expressed on motor neurons.

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Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

August 1988

Volume

3

Issue

2

Start / End Page

156 / 160

Location

United States

Related Subject Headings

  • Serotyping
  • Poliovirus
  • Poliomyelitis
  • Nucleic Acid Hybridization
  • Humans
  • Genetics & Heredity
  • Genes
  • Disease Susceptibility
  • DNA Probes
  • Chromosomes, Human, Pair 19
 

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Siddique, T., McKinney, R., Hung, W. Y., Bartlett, R. J., Bruns, G., Mohandas, T. K., … Roses, A. D. (1988). The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2. Genomics, 3(2), 156–160. https://doi.org/10.1016/0888-7543(88)90147-4
Siddique, T., R. McKinney, W. Y. Hung, R. J. Bartlett, G. Bruns, T. K. Mohandas, H. H. Ropers, C. Wilfert, and A. D. Roses. “The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2.Genomics 3, no. 2 (August 1988): 156–60. https://doi.org/10.1016/0888-7543(88)90147-4.
Siddique T, McKinney R, Hung WY, Bartlett RJ, Bruns G, Mohandas TK, et al. The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2. Genomics. 1988 Aug;3(2):156–60.
Siddique, T., et al. “The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2.Genomics, vol. 3, no. 2, Aug. 1988, pp. 156–60. Pubmed, doi:10.1016/0888-7543(88)90147-4.
Siddique T, McKinney R, Hung WY, Bartlett RJ, Bruns G, Mohandas TK, Ropers HH, Wilfert C, Roses AD. The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2. Genomics. 1988 Aug;3(2):156–160.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

August 1988

Volume

3

Issue

2

Start / End Page

156 / 160

Location

United States

Related Subject Headings

  • Serotyping
  • Poliovirus
  • Poliomyelitis
  • Nucleic Acid Hybridization
  • Humans
  • Genetics & Heredity
  • Genes
  • Disease Susceptibility
  • DNA Probes
  • Chromosomes, Human, Pair 19