Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.

Published

Journal Article

Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).

Full Text

Duke Authors

Cited Authors

  • van der Walt, JM; Martin, ER; Scott, WK; Zhang, F; Nance, MA; Watts, RL; Hubble, JP; Haines, JL; Koller, WC; Lyons, K; Pahwa, R; Stern, MB; Colcher, A; Hiner, BC; Jankovic, J; Ondo, WG; Allen, FH; Goetz, CG; Small, GW; Mastaglia, F; Roses, AD; Stajich, JM; Booze, MW; Fujiwara, K; Gibson, RA; Middleton, LT; Scott, BL; Pericak-Vance, MA; Vance, JM

Published Date

  • April 2003

Published In

Volume / Issue

  • 60 / 7

Start / End Page

  • 1189 - 1191

PubMed ID

  • 12682333

Pubmed Central ID

  • 12682333

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/01.wnl.0000055929.84668.9a

Language

  • eng