Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.

Journal Article (Journal Article)

Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod less than or equal to -2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.

Full Text

Duke Authors

Cited Authors

  • Diehl, SR; Boehnke, M; Collins, FS; Erickson, RP; Karolyi, IJ; Ploughman, LM; Pericak-Vance, MA; Aylsworth, AS; Roses, AD

Published Date

  • September 1987

Published In

Volume / Issue

  • 24 / 9

Start / End Page

  • 532 - 534

PubMed ID

  • 3118034

Pubmed Central ID

  • PMC1050261

International Standard Serial Number (ISSN)

  • 0022-2593

Digital Object Identifier (DOI)

  • 10.1136/jmg.24.9.532


  • eng

Conference Location

  • England