Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.
Publication
, Journal Article
Diehl, SR; Boehnke, M; Collins, FS; Erickson, RP; Karolyi, IJ; Ploughman, LM; Pericak-Vance, MA; Aylsworth, AS; Roses, AD
Published in: J Med Genet
September 1987
Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod less than or equal to -2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.
Duke Scholars
Published In
J Med Genet
DOI
ISSN
0022-2593
Publication Date
September 1987
Volume
24
Issue
9
Start / End Page
532 / 534
Location
England
Related Subject Headings
- Tissue Plasminogen Activator
- Thyroglobulin
- Neurofibromatosis 1
- Humans
- Genetics & Heredity
- Genetic Markers
- Genetic Linkage
- DNA
- Chromosomes, Human, Pair 8
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Diehl, S. R., Boehnke, M., Collins, F. S., Erickson, R. P., Karolyi, I. J., Ploughman, L. M., … Roses, A. D. (1987). Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8. J Med Genet, 24(9), 532–534. https://doi.org/10.1136/jmg.24.9.532
Diehl, S. R., M. Boehnke, F. S. Collins, R. P. Erickson, I. J. Karolyi, L. M. Ploughman, M. A. Pericak-Vance, A. S. Aylsworth, and A. D. Roses. “Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.” J Med Genet 24, no. 9 (September 1987): 532–34. https://doi.org/10.1136/jmg.24.9.532.
Diehl SR, Boehnke M, Collins FS, Erickson RP, Karolyi IJ, Ploughman LM, et al. Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8. J Med Genet. 1987 Sep;24(9):532–4.
Diehl, S. R., et al. “Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8.” J Med Genet, vol. 24, no. 9, Sept. 1987, pp. 532–34. Pubmed, doi:10.1136/jmg.24.9.532.
Diehl SR, Boehnke M, Collins FS, Erickson RP, Karolyi IJ, Ploughman LM, Pericak-Vance MA, Aylsworth AS, Roses AD. Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8. J Med Genet. 1987 Sep;24(9):532–534.
Published In
J Med Genet
DOI
ISSN
0022-2593
Publication Date
September 1987
Volume
24
Issue
9
Start / End Page
532 / 534
Location
England
Related Subject Headings
- Tissue Plasminogen Activator
- Thyroglobulin
- Neurofibromatosis 1
- Humans
- Genetics & Heredity
- Genetic Markers
- Genetic Linkage
- DNA
- Chromosomes, Human, Pair 8
- 3202 Clinical sciences