Sequestration of amyloid beta-peptide.

Published

Journal Article (Review)

Amyloid beta-protein, or beta/A4, is a 4-kilodalton peptide that forms poorly soluble extracellular depositions of amyloid in brains and leptomeninges of patients with Alzheimer's disease (AD), Down's syndrome (DS), and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). beta/A4 peptide is a derivative of a large transmembrane glycoprotein (APP) and is found in the extracellular space, i.e., in the cerebrospinal fluid and serum of individuals with and without AD and in the conditioned media of many different cells grown in culture. The mechanism by which normally produced amyloid beta peptide forms extracellular aggregates in patients is unknown. One possible explanation is a failure of a mechanism for removal of the beta/A4 peptide that prevents this highly aggregating peptide from forming extracellular amyloid depositions.

Full Text

Duke Authors

Cited Authors

  • Goldgaber, D; Schwarzman, AI; Bhasin, R; Gregori, L; Schmechel, D; Saunders, AM; Roses, AD; Strittmatter, WJ

Published Date

  • September 1993

Published In

Volume / Issue

  • 695 /

Start / End Page

  • 139 - 143

PubMed ID

  • 8239272

Pubmed Central ID

  • 8239272

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.1993.tb23042.x

Language

  • eng