A prospective study of thymectomy and serum acetylcholine receptor antibodies in myasthenia gravis.


Journal Article

Forty-seven consecutively presenting myasthenia gravis (MG) patients with generalized weakness were treated according to a standardized prospective protocol. All patients underwent a sternal splitting "total" thymectomy. Medical status before surgery was optimized by plasmapheresis without immunosuppression. Medications were avoided or discontinued whenever possible. All patients were improved. At the time of latest follow-up 83% were free of generalized weakness and 61% were on no medications. There was no significant change in Acetylcholine Receptor Antibody (AChR-AB) titer. The following conclusions were made: (1) thymectomy is an effective therapy for MG, (2) additional medications are not necessary in the majority of patients, and (3) a reduction in the AChR-AB titer is not essential for clinical benefit.

Full Text

Cited Authors

  • Olanow, CW; Wechsler, AS; Roses, AD

Published Date

  • August 1, 1982

Published In

Volume / Issue

  • 196 / 2

Start / End Page

  • 113 - 121

PubMed ID

  • 7092360

Pubmed Central ID

  • 7092360

Electronic International Standard Serial Number (EISSN)

  • 1528-1140

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/00000658-198208000-00001


  • eng