Promiscuous expression of myosin in myotonic dystrophy.

Published

Journal Article

The pathologic changes in myotonic dystrophy (DM) skeletal muscle biopsies have been analyzed at both the histochemical and molecular level. A histochemical stain for pretyping single fibers in conjunction with sodium dodecyl sulphate-polyacrylamide gel electrophoresis allowed biochemical differences to be pinpointed in specific histochemical fiber types. These biochemical differences can be related to histochemical changes in fiber type observed in cross-section of the DM biopsies. Such changes included specific fiber type atrophy, hypertrophy, and disproportion. The pathogenesis of DM appears to be characterized by a large increase in the number of promiscuous fibers, that is, those fibers that express both fast and slow myosins. This promiscuity, which is rare in control muscle (less than 2%), is also prevalent at high levels in some family members at risk for DM. The observed promiscuity, although probably not a primary effect of DM, appears to be linked to the histochemical changes in fiber type observed in the DM biopsies.

Full Text

Duke Authors

Cited Authors

  • Moore, GE; Roses, AD; Pericak-Vance, MA; Garrett, WE; Schachat, FH

Published Date

  • May 1, 1986

Published In

Volume / Issue

  • 9 / 4

Start / End Page

  • 355 - 363

PubMed ID

  • 3713741

Pubmed Central ID

  • 3713741

International Standard Serial Number (ISSN)

  • 0148-639X

Digital Object Identifier (DOI)

  • 10.1002/mus.880090413

Language

  • eng

Conference Location

  • United States