SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.
Journal Article (Journal Article)
There has been great interest in the prospects of using single-nucleotide polymorphisms (SNPs) in the search for complex disease genes, and several initiatives devoted to the identification and mapping of SNPs throughout the human genome are currently underway. However, actual data investigating the use of SNPs for identification of complex disease genes are scarce. To begin to look at issues surrounding the use of SNPs in complex disease studies, we have initiated a collaborative SNP mapping study around APOE, the well-established susceptibility gene for late-onset Alzheimer disease (AD). Sixty SNPs in a 1.5-Mb region surrounding APOE were genotyped in samples of unrelated cases of AD, in controls, and in families with AD. Standard tests were conducted to look for association of SNP alleles with AD, in cases and controls. We also used family-based association analyses, including recently developed methods to look for haplotype association. Evidence of association (P
Full Text
Duke Authors
Cited Authors
- Martin, ER; Lai, EH; Gilbert, JR; Rogala, AR; Afshari, AJ; Riley, J; Finch, KL; Stevens, JF; Livak, KJ; Slotterbeck, BD; Slifer, SH; Warren, LL; Conneally, PM; Schmechel, DE; Purvis, I; Pericak-Vance, MA; Roses, AD; Vance, JM
Published Date
- August 2000
Published In
Volume / Issue
- 67 / 2
Start / End Page
- 383 - 394
PubMed ID
- 10869235
Pubmed Central ID
- PMC1287185
International Standard Serial Number (ISSN)
- 0002-9297
Digital Object Identifier (DOI)
- 10.1086/303003
Language
- eng
Conference Location
- United States