SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.

Journal Article (Journal Article)

There has been great interest in the prospects of using single-nucleotide polymorphisms (SNPs) in the search for complex disease genes, and several initiatives devoted to the identification and mapping of SNPs throughout the human genome are currently underway. However, actual data investigating the use of SNPs for identification of complex disease genes are scarce. To begin to look at issues surrounding the use of SNPs in complex disease studies, we have initiated a collaborative SNP mapping study around APOE, the well-established susceptibility gene for late-onset Alzheimer disease (AD). Sixty SNPs in a 1.5-Mb region surrounding APOE were genotyped in samples of unrelated cases of AD, in controls, and in families with AD. Standard tests were conducted to look for association of SNP alleles with AD, in cases and controls. We also used family-based association analyses, including recently developed methods to look for haplotype association. Evidence of association (P

Full Text

Duke Authors

Cited Authors

  • Martin, ER; Lai, EH; Gilbert, JR; Rogala, AR; Afshari, AJ; Riley, J; Finch, KL; Stevens, JF; Livak, KJ; Slotterbeck, BD; Slifer, SH; Warren, LL; Conneally, PM; Schmechel, DE; Purvis, I; Pericak-Vance, MA; Roses, AD; Vance, JM

Published Date

  • August 2000

Published In

Volume / Issue

  • 67 / 2

Start / End Page

  • 383 - 394

PubMed ID

  • 10869235

Pubmed Central ID

  • PMC1287185

International Standard Serial Number (ISSN)

  • 0002-9297

Digital Object Identifier (DOI)

  • 10.1086/303003


  • eng

Conference Location

  • United States