Genetics of Alzheimer's disease.


Journal Article (Review)

Alzheimer's disease is the leading cause of dementia in the elderly. Most patients do not have an obvious family history and are classified as sporadic. Genetic factors in early and late-onset Alzheimer's disease are now well documented. This paper reviews the known genetic loci associated with Alzheimer's disease with an emphasis on the role of apolipoprotein E in late-onset familial and sporadic disease. Apolipoprotein E allele 4 is a susceptibility gene that is found in approximately 50% of patients with Alzheimer's disease. Hypotheses about apolipoprotein E function that may lead to Alzheimer's disease are also discussed.

Full Text

Duke Authors

Cited Authors

  • Burke, JR; Roses, AD

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 25-26 /

Start / End Page

  • 41 - 51

PubMed ID

  • 11980062

Pubmed Central ID

  • 11980062

International Standard Serial Number (ISSN)

  • 0020-7446


  • eng