Genetics of Alzheimer's disease.
Publication
, Journal Article
Burke, JR; Roses, AD
Published in: Int J Neurol
1991
Alzheimer's disease is the leading cause of dementia in the elderly. Most patients do not have an obvious family history and are classified as sporadic. Genetic factors in early and late-onset Alzheimer's disease are now well documented. This paper reviews the known genetic loci associated with Alzheimer's disease with an emphasis on the role of apolipoprotein E in late-onset familial and sporadic disease. Apolipoprotein E allele 4 is a susceptibility gene that is found in approximately 50% of patients with Alzheimer's disease. Hypotheses about apolipoprotein E function that may lead to Alzheimer's disease are also discussed.
Duke Scholars
Published In
Int J Neurol
ISSN
0020-7446
Publication Date
1991
Volume
25-26
Start / End Page
41 / 51
Location
Uruguay
Related Subject Headings
- Humans
- Chromosomes
- Apolipoproteins E
- Animals
- Alzheimer Disease
- Age of Onset
Citation
APA
Chicago
ICMJE
MLA
NLM
Burke, J. R., & Roses, A. D. (1991). Genetics of Alzheimer's disease. Int J Neurol, 25–26, 41–51.
Burke, J. R., and A. D. Roses. “Genetics of Alzheimer's disease.” Int J Neurol 25–26 (1991): 41–51.
Burke JR, Roses AD. Genetics of Alzheimer's disease. Int J Neurol. 1991;25–26:41–51.
Burke, J. R., and A. D. Roses. “Genetics of Alzheimer's disease.” Int J Neurol, vol. 25–26, 1991, pp. 41–51.
Burke JR, Roses AD. Genetics of Alzheimer's disease. Int J Neurol. 1991;25–26:41–51.
Published In
Int J Neurol
ISSN
0020-7446
Publication Date
1991
Volume
25-26
Start / End Page
41 / 51
Location
Uruguay
Related Subject Headings
- Humans
- Chromosomes
- Apolipoproteins E
- Animals
- Alzheimer Disease
- Age of Onset