Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease.
Publication
, Journal Article
Peacock, ML; Warren, JT; Roses, AD; Fink, JK
Published in: Neurology
June 1993
We found a novel polymorphism in the amyloid precursor protein (APP) gene in a patient with ischemic cerebrovascular disease who had no evidence of Alzheimer's disease (AD). This polymorphism deletes a Fok I restriction enzyme site and causes the substitution of threonine for alanine at codon 673. This is adjacent to the site at which APP is thought to undergo cleavage in AD. Analysis of this polymorphism may provide insight into the basis of APP processing.
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Published In
Neurology
DOI
EISSN
1526-632X
ISSN
0028-3878
Publication Date
June 1993
Volume
43
Issue
6
Start / End Page
1254 / 1256
Related Subject Headings
- Reference Values
- Polymorphism, Genetic
- Neurology & Neurosurgery
- Humans
- Cerebrovascular Disorders
- Amyloid beta-Protein Precursor
- Alzheimer Disease
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Peacock, M. L., Warren, J. T., Roses, A. D., & Fink, J. K. (1993). Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease. Neurology, 43(6), 1254–1256. https://doi.org/10.1212/wnl.43.6.1254
Peacock, M. L., J. T. Warren, A. D. Roses, and J. K. Fink. “Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease.” Neurology 43, no. 6 (June 1993): 1254–56. https://doi.org/10.1212/wnl.43.6.1254.
Peacock ML, Warren JT, Roses AD, Fink JK. Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease. Neurology. 1993 Jun;43(6):1254–6.
Peacock, M. L., et al. “Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease.” Neurology, vol. 43, no. 6, June 1993, pp. 1254–56. Epmc, doi:10.1212/wnl.43.6.1254.
Peacock ML, Warren JT, Roses AD, Fink JK. Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease. Neurology. 1993 Jun;43(6):1254–1256.
Published In
Neurology
DOI
EISSN
1526-632X
ISSN
0028-3878
Publication Date
June 1993
Volume
43
Issue
6
Start / End Page
1254 / 1256
Related Subject Headings
- Reference Values
- Polymorphism, Genetic
- Neurology & Neurosurgery
- Humans
- Cerebrovascular Disorders
- Amyloid beta-Protein Precursor
- Alzheimer Disease
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences