Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia.


Journal Article

There is accumulating evidence that apolipoprotein E (apoE) plays a role in regulating the response to and outcome following brain injury. The present study compared the histological outcome and recovery following an episode of global ischaemia in apoE-deficient mice and wild-type littermates (12-week-old males, n = 8 per group). Transient global ischaemia was induced for a period of 17 min and the animals were allowed to recover for 72 h. Transient global ischaemia induced selective neuronal degeneration in several brain regions in wild-type mice. There was statistically significant increased ischaemic neuronal damage in apoE-deficient mice compared with wild-type mice in six of the seven regions examined (hippocampal regions CA1, CA3/CA4 and dentate gyrus; thalamus; cortex and caudate nucleus; P < 0.05). The data substantiate a role for apoE in modifying the response of the CNS to acute injury.

Full Text

Cited Authors

  • Horsburgh, K; Kelly, S; McCulloch, J; Higgins, GA; Roses, AD; Nicoll, JA

Published Date

  • March 1999

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 837 - 841

PubMed ID

  • 10208557

Pubmed Central ID

  • 10208557

Electronic International Standard Serial Number (EISSN)

  • 1473-558X

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199903170-00031


  • eng