Splicing of an anti-sense Alu sequence generates a coding sequence variant for the alpha-3 subunit of a neuronal acetylcholine receptor.


Journal Article

In this report we demonstrate that an alpha-3 acetylcholine receptor subunit transcriptional variant originates through alternative splicing of a complementary sequence of the right arm of an Alu element. This element is located within the 5.1 Kb intron found between exons 5 and 6 of the alpha-3 acetylcholine receptor subunit gene. The transcriptional variant originates from the normal splicing process and carries an in-frame stop codon. If translated, it should encode for a peptide lacking the 4th transmembrane domain of the normal subunit.

Full Text

Cited Authors

  • Mihovilovic, M; Mai, Y; Herbstreith, M; Rubboli, F; Tarroni, P; Clementi, F; Roses, AD

Published Date

  • November 1993

Published In

Volume / Issue

  • 197 / 1

Start / End Page

  • 137 - 144

PubMed ID

  • 8250918

Pubmed Central ID

  • 8250918

Electronic International Standard Serial Number (EISSN)

  • 1090-2104

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1993.2452


  • eng