Association between bleomycin hydrolase and Alzheimer's disease in caucasians.

Journal Article (Journal Article)

A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.

Full Text

Duke Authors

Cited Authors

  • Farrer, LA; Abraham, CR; Haines, JL; Rogaeva, EA; Song, Y; McGraw, WT; Brindle, N; Premkumar, S; Scott, WK; Yamaoka, LH; Saunders, AM; Roses, AD; Auerbach, SA; Sorbi, S; Duara, R; Pericak-Vance, MA; St George-Hyslop, PH

Published Date

  • November 1998

Published In

Volume / Issue

  • 44 / 5

Start / End Page

  • 808 - 811

PubMed ID

  • 9818937

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.410440515


  • eng

Conference Location

  • United States