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Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases?

Publication ,  Journal Article
Cooper, AJ; Sheu, KF; Burke, JR; Onodera, O; Strittmatter, WJ; Roses, AD; Blass, JP
Published in: J Neurochem
July 1997

Huntington's disease and six other neurodegenerative diseases are associated with abnormal gene products containing expanded polyglutamine (poly-Q; Qn) domains (n > or = 40). In the present work, we show that glutathione S-transferase (GST) fusion proteins containing a small, physiological-length poly-Q domain (GSTQ10) or a large, pathological-length poly-Q domain (GSTQ62) are excellent substrates of guinea pig liver (tissue) transglutaminase and that both GSTQ10 and GSTQ62 are activators of tissue transglutaminase-catalyzed hydroxaminolysis of N-alpha-carbobenzoxyglutaminylglycine. The present findings have implications for understanding the pathophysiological mechanisms of expanded CAG/poly-Q domain diseases.

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Published In

J Neurochem

DOI

ISSN

0022-3042

Publication Date

July 1997

Volume

69

Issue

1

Start / End Page

431 / 434

Location

England

Related Subject Headings

  • Transglutaminases
  • Substrate Specificity
  • Repetitive Sequences, Nucleic Acid
  • Protein Structure, Tertiary
  • Peptides
  • Neurology & Neurosurgery
  • Nerve Degeneration
  • Liver
  • Guinea Pigs
  • Brain
 

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Cooper, A. J., Sheu, K. F., Burke, J. R., Onodera, O., Strittmatter, W. J., Roses, A. D., & Blass, J. P. (1997). Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? J Neurochem, 69(1), 431–434. https://doi.org/10.1046/j.1471-4159.1997.69010431.x
Cooper, A. J., K. F. Sheu, J. R. Burke, O. Onodera, W. J. Strittmatter, A. D. Roses, and J. P. Blass. “Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases?J Neurochem 69, no. 1 (July 1997): 431–34. https://doi.org/10.1046/j.1471-4159.1997.69010431.x.
Cooper AJ, Sheu KF, Burke JR, Onodera O, Strittmatter WJ, Roses AD, et al. Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? J Neurochem. 1997 Jul;69(1):431–4.
Cooper, A. J., et al. “Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases?J Neurochem, vol. 69, no. 1, July 1997, pp. 431–34. Pubmed, doi:10.1046/j.1471-4159.1997.69010431.x.
Cooper AJ, Sheu KF, Burke JR, Onodera O, Strittmatter WJ, Roses AD, Blass JP. Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? J Neurochem. 1997 Jul;69(1):431–434.
Journal cover image

Published In

J Neurochem

DOI

ISSN

0022-3042

Publication Date

July 1997

Volume

69

Issue

1

Start / End Page

431 / 434

Location

England

Related Subject Headings

  • Transglutaminases
  • Substrate Specificity
  • Repetitive Sequences, Nucleic Acid
  • Protein Structure, Tertiary
  • Peptides
  • Neurology & Neurosurgery
  • Nerve Degeneration
  • Liver
  • Guinea Pigs
  • Brain