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Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).

Publication ,  Journal Article
Grubber, JM; Saunders, AM; Crane-Gatherum, AR; Scott, WK; Martin, ER; Haynes, CS; Conneally, PM; Small, GW; Roses, AD; Haines, JL; Pericak-Vance, MA
Published in: Neurosci Lett
July 9, 1999

Butyrylcholinesterase (BCHE) is an enzyme expressed in most human tissues. Recently, an increased odds of carrying the K variant of BCHE (BCHE-K) was reported among Alzheimer disease (AD) cases as compared with controls. We tested our data set of 245 sporadic AD cases and 241 controls for an association between BCHE-K, APOE4, and AD using logistic regression and chi-square analyses. The sib transmission disequilibrium test (S-TDT) was also used to test for differences in BCHE-K allele frequencies between 163 discordant sib-pairs selected from multiplex AD families. No statistically significant differences were noted between BCHE-K case and control allele frequencies even after stratifying by APOE4 status. S-TDT analysis between the BCHE-K variant and AD was also not significant (P = 0.52). We conclude that BCHE-K is not a major genetic risk factor for AD in our study population.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 9, 1999

Volume

269

Issue

2

Start / End Page

115 / 119

Location

Ireland

Related Subject Headings

  • Pedigree
  • Odds Ratio
  • Nuclear Family
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Female
  • Case-Control Studies
  • Butyrylcholinesterase
 

Citation

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Grubber, J. M., Saunders, A. M., Crane-Gatherum, A. R., Scott, W. K., Martin, E. R., Haynes, C. S., … Pericak-Vance, M. A. (1999). Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). Neurosci Lett, 269(2), 115–119. https://doi.org/10.1016/s0304-3940(99)00426-7
Grubber, J. M., A. M. Saunders, A. R. Crane-Gatherum, W. K. Scott, E. R. Martin, C. S. Haynes, P. M. Conneally, et al. “Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).Neurosci Lett 269, no. 2 (July 9, 1999): 115–19. https://doi.org/10.1016/s0304-3940(99)00426-7.
Grubber JM, Saunders AM, Crane-Gatherum AR, Scott WK, Martin ER, Haynes CS, et al. Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). Neurosci Lett. 1999 Jul 9;269(2):115–9.
Grubber, J. M., et al. “Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).Neurosci Lett, vol. 269, no. 2, July 1999, pp. 115–19. Pubmed, doi:10.1016/s0304-3940(99)00426-7.
Grubber JM, Saunders AM, Crane-Gatherum AR, Scott WK, Martin ER, Haynes CS, Conneally PM, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). Neurosci Lett. 1999 Jul 9;269(2):115–119.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 9, 1999

Volume

269

Issue

2

Start / End Page

115 / 119

Location

Ireland

Related Subject Headings

  • Pedigree
  • Odds Ratio
  • Nuclear Family
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Female
  • Case-Control Studies
  • Butyrylcholinesterase