Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).
Journal Article (Journal Article)
Butyrylcholinesterase (BCHE) is an enzyme expressed in most human tissues. Recently, an increased odds of carrying the K variant of BCHE (BCHE-K) was reported among Alzheimer disease (AD) cases as compared with controls. We tested our data set of 245 sporadic AD cases and 241 controls for an association between BCHE-K, APOE4, and AD using logistic regression and chi-square analyses. The sib transmission disequilibrium test (S-TDT) was also used to test for differences in BCHE-K allele frequencies between 163 discordant sib-pairs selected from multiplex AD families. No statistically significant differences were noted between BCHE-K case and control allele frequencies even after stratifying by APOE4 status. S-TDT analysis between the BCHE-K variant and AD was also not significant (P = 0.52). We conclude that BCHE-K is not a major genetic risk factor for AD in our study population.
Full Text
Duke Authors
Cited Authors
- Grubber, JM; Saunders, AM; Crane-Gatherum, AR; Scott, WK; Martin, ER; Haynes, CS; Conneally, PM; Small, GW; Roses, AD; Haines, JL; Pericak-Vance, MA
Published Date
- July 9, 1999
Published In
Volume / Issue
- 269 / 2
Start / End Page
- 115 - 119
PubMed ID
- 10430518
International Standard Serial Number (ISSN)
- 0304-3940
Digital Object Identifier (DOI)
- 10.1016/s0304-3940(99)00426-7
Language
- eng
Conference Location
- Ireland