Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2.

Journal Article (Journal Article)

Charcot-Marie-Tooth (CMT) disease type 1a has been previously localized to chromosome 17 using the markers D17S58 and D17S71. In that report we were unable to provide unequivocal localization of the CMT1A gene on either the proximal p or the q arm. Therefore, data from one additional CMT1A family and typing of other probes spanning the pericentromeric region of chromosome 17 (D17S73, D17S58, D17S122, D17S125, D17S124) were analyzed. Multipoint analysis demonstrates convincing evidence (log likelihood difference greater than 5) that the CMT1A gene lies within 17p11.2 and most likely between the flanking markers D17S122 and D17S124.

Full Text

Duke Authors

Cited Authors

  • Vance, JM; Barker, D; Yamaoka, LH; Stajich, JM; Loprest, L; Hung, WY; Fischbeck, K; Roses, AD; Pericak-Vance, MA

Published Date

  • April 1991

Published In

Volume / Issue

  • 9 / 4

Start / End Page

  • 623 - 628

PubMed ID

  • 1674726

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(91)90355-i


  • eng

Conference Location

  • United States