Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2.
Publication
, Journal Article
Vance, JM; Barker, D; Yamaoka, LH; Stajich, JM; Loprest, L; Hung, WY; Fischbeck, K; Roses, AD; Pericak-Vance, MA
Published in: Genomics
April 1991
Charcot-Marie-Tooth (CMT) disease type 1a has been previously localized to chromosome 17 using the markers D17S58 and D17S71. In that report we were unable to provide unequivocal localization of the CMT1A gene on either the proximal p or the q arm. Therefore, data from one additional CMT1A family and typing of other probes spanning the pericentromeric region of chromosome 17 (D17S73, D17S58, D17S122, D17S125, D17S124) were analyzed. Multipoint analysis demonstrates convincing evidence (log likelihood difference greater than 5) that the CMT1A gene lies within 17p11.2 and most likely between the flanking markers D17S122 and D17S124.
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Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
April 1991
Volume
9
Issue
4
Start / End Page
623 / 628
Location
United States
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Male
- Lod Score
- Humans
- Genetics & Heredity
- Genetic Linkage
- Female
- DNA Probes
- Chromosomes, Human, Pair 17
- Chromosome Mapping
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Vance, J. M., Barker, D., Yamaoka, L. H., Stajich, J. M., Loprest, L., Hung, W. Y., … Pericak-Vance, M. A. (1991). Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2. Genomics, 9(4), 623–628. https://doi.org/10.1016/0888-7543(91)90355-i
Vance, J. M., D. Barker, L. H. Yamaoka, J. M. Stajich, L. Loprest, W. Y. Hung, K. Fischbeck, A. D. Roses, and M. A. Pericak-Vance. “Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2.” Genomics 9, no. 4 (April 1991): 623–28. https://doi.org/10.1016/0888-7543(91)90355-i.
Vance JM, Barker D, Yamaoka LH, Stajich JM, Loprest L, Hung WY, et al. Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2. Genomics. 1991 Apr;9(4):623–8.
Vance, J. M., et al. “Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2.” Genomics, vol. 9, no. 4, Apr. 1991, pp. 623–28. Pubmed, doi:10.1016/0888-7543(91)90355-i.
Vance JM, Barker D, Yamaoka LH, Stajich JM, Loprest L, Hung WY, Fischbeck K, Roses AD, Pericak-Vance MA. Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2. Genomics. 1991 Apr;9(4):623–628.
Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
April 1991
Volume
9
Issue
4
Start / End Page
623 / 628
Location
United States
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Male
- Lod Score
- Humans
- Genetics & Heredity
- Genetic Linkage
- Female
- DNA Probes
- Chromosomes, Human, Pair 17
- Chromosome Mapping