A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene.

Published

Journal Article

A human muscle cDNA library was screened for slow skeletal troponin T (TnTs). Sequence analysis revealed that one of the selected clones had a cDNA coding sequence different from the two previously described. RNase protection assays confirmed the expression of this new isoform in adult skeletal muscle. In addition, results of the RNase protection assays strongly suggested the expression of a fourth isoform. These isoforms for human slow TnT most likely result from combinatorial alternative splicing of a single gene.

Full Text

Cited Authors

  • Samson, F; Mesnard, L; Mihovilovic, M; Potter, TG; Mercadier, JJ; Roses, AD; Gilbert, JR

Published Date

  • March 1994

Published In

Volume / Issue

  • 199 / 2

Start / End Page

  • 841 - 847

PubMed ID

  • 8135831

Pubmed Central ID

  • 8135831

Electronic International Standard Serial Number (EISSN)

  • 1090-2104

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1994.1305

Language

  • eng