Pharmacogenetics place in modern medical science and practice.

Published

Journal Article (Review)

Pharmacogenetic evidence-based treatment strategies will have major implications for all aspects of the product pipeline, including drug discovery, high throughput target screening protocols, lead optimization, and drug formulation to produce series of medicines for a particular disease which will meet the efficacy needs of the majority of patients. The initial proof of principle experiments involves whole genome screening for DNA variants and determination of specific patterns of variants associated with adverse events of marketed products [SNP Print(sm)]. Pharmacogenetics has the potential of changing the pipeline model of drug discovery, clinical development, and mass customization marketing.

Full Text

Cited Authors

  • Roses, AD

Published Date

  • February 2002

Published In

Volume / Issue

  • 70 / 13

Start / End Page

  • 1471 - 1480

PubMed ID

  • 11895098

Pubmed Central ID

  • 11895098

Electronic International Standard Serial Number (EISSN)

  • 1879-0631

International Standard Serial Number (ISSN)

  • 1879-0631

Digital Object Identifier (DOI)

  • 10.1016/s0024-3205(01)01532-6

Language

  • eng