Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2).

Journal Article (Journal Article)

The transverse relaxation time, T *(2), of hyperpolarized (HP) gas in the lung in vivo is an important parameter for pulse sequence optimization and image contrast. We obtained T *(2) maps of HP (3)He and (129)Xe in guinea pig lungs (n = 17) and in human lungs. Eight different sets of (3)He guinea pig studies were acquired, with variation of slice selection, tidal volume, and oxygen level. For example, for a (3)He tidal volume of 3 cm(3) and no slice selection, the average T *(2) in the trachea was 14.7 ms and 8.0 ms in the intrapulmonary airspaces. The equivalent (129)Xe experiment yielded an average T *(2) of 40.8 ms in the trachea and 18.5 ms in the intrapulmonary airspaces. The average (3)He T *(2) in the human intrapulmonary airspaces was 9.4 ms. The relaxation behavior was predicted by treating the lung as a porous medium, resulting in good agreement between estimated and measured T *(2) values in the intrapulmonary airspaces. Magn Reson Med 42:729-737, 1999.

Full Text

Duke Authors

Cited Authors

  • Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; MacFall, JR; Johnson, GA

Published Date

  • October 1999

Published In

Volume / Issue

  • 42 / 4

Start / End Page

  • 729 - 737

PubMed ID

  • 10502762

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/(sici)1522-2594(199910)42:4<729::aid-mrm15>;2-2


  • eng

Conference Location

  • United States