Skip to main content
Journal cover image

Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.

Publication ,  Journal Article
Spector, ZZ; Emami, K; Fischer, MC; Zhu, J; Ishii, M; Vahdat, V; Yu, J; Kadlecek, S; Driehuys, B; Lipson, DA; Gefter, W; Shrager, J; Rizi, RR
Published in: Magn Reson Med
June 2005

In this experiment, Sprague-Dawley rats with elastase-induced emphysema were imaged using hyperpolarized (3)He MRI. Regional fractional ventilation r, the fraction of gas replaced with a single tidal breath, was calculated from a series of images in a wash-in study of hyperpolarized gas. We compared the regional fractional ventilation in these emphysematous rats to the regional fractional ventilations we calculated from a previous baseline study in healthy Sprague-Dawley rats. We found that there were differences in the maps of fractional ventilation and its associated frequency distribution between the healthy and emphysematous rat lungs. Fractional ventilation tended to be much lower in emphysematous rats than in normal rats. With this information, we can use data on fractional ventilation to regionally distinguish between healthy and emphysematous portions of the lung. The successful implementation of such a technique on a rat model could lead to work toward the future implementation of this technique in human patients.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

June 2005

Volume

53

Issue

6

Start / End Page

1341 / 1346

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pulmonary Ventilation
  • Pulmonary Emphysema
  • Pancreatic Elastase
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Isotopes
  • Image Processing, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Spector, Z. Z., Emami, K., Fischer, M. C., Zhu, J., Ishii, M., Vahdat, V., … Rizi, R. R. (2005). Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging. Magn Reson Med, 53(6), 1341–1346. https://doi.org/10.1002/mrm.20514
Spector, Z. Z., K. Emami, M. C. Fischer, J. Zhu, M. Ishii, V. Vahdat, J. Yu, et al. “Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.Magn Reson Med 53, no. 6 (June 2005): 1341–46. https://doi.org/10.1002/mrm.20514.
Spector ZZ, Emami K, Fischer MC, Zhu J, Ishii M, Vahdat V, et al. Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging. Magn Reson Med. 2005 Jun;53(6):1341–6.
Spector, Z. Z., et al. “Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.Magn Reson Med, vol. 53, no. 6, June 2005, pp. 1341–46. Pubmed, doi:10.1002/mrm.20514.
Spector ZZ, Emami K, Fischer MC, Zhu J, Ishii M, Vahdat V, Yu J, Kadlecek S, Driehuys B, Lipson DA, Gefter W, Shrager J, Rizi RR. Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging. Magn Reson Med. 2005 Jun;53(6):1341–1346.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

June 2005

Volume

53

Issue

6

Start / End Page

1341 / 1346

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pulmonary Ventilation
  • Pulmonary Emphysema
  • Pancreatic Elastase
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Isotopes
  • Image Processing, Computer-Assisted