Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.

Journal Article (Journal Article)

In this experiment, Sprague-Dawley rats with elastase-induced emphysema were imaged using hyperpolarized (3)He MRI. Regional fractional ventilation r, the fraction of gas replaced with a single tidal breath, was calculated from a series of images in a wash-in study of hyperpolarized gas. We compared the regional fractional ventilation in these emphysematous rats to the regional fractional ventilations we calculated from a previous baseline study in healthy Sprague-Dawley rats. We found that there were differences in the maps of fractional ventilation and its associated frequency distribution between the healthy and emphysematous rat lungs. Fractional ventilation tended to be much lower in emphysematous rats than in normal rats. With this information, we can use data on fractional ventilation to regionally distinguish between healthy and emphysematous portions of the lung. The successful implementation of such a technique on a rat model could lead to work toward the future implementation of this technique in human patients.

Full Text

Duke Authors

Cited Authors

  • Spector, ZZ; Emami, K; Fischer, MC; Zhu, J; Ishii, M; Vahdat, V; Yu, J; Kadlecek, S; Driehuys, B; Lipson, DA; Gefter, W; Shrager, J; Rizi, RR

Published Date

  • June 2005

Published In

Volume / Issue

  • 53 / 6

Start / End Page

  • 1341 - 1346

PubMed ID

  • 15906306

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.20514


  • eng

Conference Location

  • United States