Molecular MRI for sensitive and specific detection of lung metastases.

Journal Article (Journal Article)

Early and specific detection of metastatic cancer cells in the lung (the most common organ targeted by metastases) could significantly improve cancer treatment outcomes. However, the most widespread lung imaging methods use ionizing radiation and have low sensitivity and/or low specificity for cancer cells. Here we address this problem with an imaging method to detect submillimeter-sized metastases with molecular specificity. Cancer cells are targeted by iron oxide nanoparticles functionalized with cancer-binding ligands, then imaged by high-resolution hyperpolarized (3)He MRI. We demonstrate in vivo detection of pulmonary micrometastates in mice injected with breast adenocarcinoma cells. The method not only holds promise for cancer imaging but more generally suggests a fundamentally unique approach to molecular imaging in the lungs.

Full Text

Duke Authors

Cited Authors

  • Branca, RT; Cleveland, ZI; Fubara, B; Kumar, CSSR; Maronpot, RR; Leuschner, C; Warren, WS; Driehuys, B

Published Date

  • February 23, 2010

Published In

Volume / Issue

  • 107 / 8

Start / End Page

  • 3693 - 3697

PubMed ID

  • 20142483

Pubmed Central ID

  • PMC2840507

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.1000386107


  • eng

Conference Location

  • United States