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Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.

Publication ,  Journal Article
Möller, HE; Chawla, MS; Chen, XJ; Driehuys, B; Hedlund, LW; Wheeler, CT; Johnson, GA
Published in: Magn Reson Med
May 1999

Hyperpolarized (HP) 129Xe can be dissolved in biologically compatible lipid emulsions while maintaining sufficient polarization for in vivo vascular imaging. For xenon in Intralipid 30%, in vitro spectroscopy at 2 T yielded a chemical shift of 197 +/- 1 ppm with reference to xenon gas, a spin-lattice relaxation time T1 = 25.3 +/- 2.1 sec, and a T2* time constant of 37 +/- 5 msec. Angiograms of the abdominal and pelvic veins in the rat obtained with 129Xe MRI after intravenous injection of HP 129Xe/Intralipid 30% into the tail demonstrated signal-to-noise ratios between 8 and 29. An analysis of the inflow effect on time-of-flight images of two segments of the inferior vena cava yielded additional information. The mean blood flow velocity was 34.7 +/- 1.0 mm/sec between the junction of the caudal veins and the kidneys and 13.3 +/- 0.8 mm/sec at the position of the diaphragm. The mean volume flow rates in these segments were 7.2 +/- 3.4 ml/min and 11.0 +/- 2.8 ml/min, respectively. Intravenous delivery of HP 129Xe dissolved in a carrier may lead to novel biomedical applications of laser-polarized gases.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

May 1999

Volume

41

Issue

5

Start / End Page

1058 / 1064

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Vena Cava, Inferior
  • Veins
  • Signal Processing, Computer-Assisted
  • Renal Veins
  • Rats
  • Pelvis
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy
 

Citation

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MLA
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Möller, H. E., Chawla, M. S., Chen, X. J., Driehuys, B., Hedlund, L. W., Wheeler, C. T., & Johnson, G. A. (1999). Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion. Magn Reson Med, 41(5), 1058–1064. https://doi.org/10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm26>3.0.co;2-c
Möller, H. E., M. S. Chawla, X. J. Chen, B. Driehuys, L. W. Hedlund, C. T. Wheeler, and G. A. Johnson. “Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.Magn Reson Med 41, no. 5 (May 1999): 1058–64. https://doi.org/10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm26>3.0.co;2-c.
Möller HE, Chawla MS, Chen XJ, Driehuys B, Hedlund LW, Wheeler CT, et al. Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion. Magn Reson Med. 1999 May;41(5):1058–64.
Möller, H. E., et al. “Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.Magn Reson Med, vol. 41, no. 5, May 1999, pp. 1058–64. Pubmed, doi:10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm26>3.0.co;2-c.
Möller HE, Chawla MS, Chen XJ, Driehuys B, Hedlund LW, Wheeler CT, Johnson GA. Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion. Magn Reson Med. 1999 May;41(5):1058–1064.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

May 1999

Volume

41

Issue

5

Start / End Page

1058 / 1064

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Vena Cava, Inferior
  • Veins
  • Signal Processing, Computer-Assisted
  • Renal Veins
  • Rats
  • Pelvis
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy