Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.
Published
Journal Article
Hyperpolarized (HP) 129Xe can be dissolved in biologically compatible lipid emulsions while maintaining sufficient polarization for in vivo vascular imaging. For xenon in Intralipid 30%, in vitro spectroscopy at 2 T yielded a chemical shift of 197 +/- 1 ppm with reference to xenon gas, a spin-lattice relaxation time T1 = 25.3 +/- 2.1 sec, and a T2* time constant of 37 +/- 5 msec. Angiograms of the abdominal and pelvic veins in the rat obtained with 129Xe MRI after intravenous injection of HP 129Xe/Intralipid 30% into the tail demonstrated signal-to-noise ratios between 8 and 29. An analysis of the inflow effect on time-of-flight images of two segments of the inferior vena cava yielded additional information. The mean blood flow velocity was 34.7 +/- 1.0 mm/sec between the junction of the caudal veins and the kidneys and 13.3 +/- 0.8 mm/sec at the position of the diaphragm. The mean volume flow rates in these segments were 7.2 +/- 3.4 ml/min and 11.0 +/- 2.8 ml/min, respectively. Intravenous delivery of HP 129Xe dissolved in a carrier may lead to novel biomedical applications of laser-polarized gases.
Full Text
Duke Authors
Cited Authors
- Möller, HE; Chawla, MS; Chen, XJ; Driehuys, B; Hedlund, LW; Wheeler, CT; Johnson, GA
Published Date
- May 1999
Published In
Volume / Issue
- 41 / 5
Start / End Page
- 1058 - 1064
PubMed ID
- 10332890
Pubmed Central ID
- 10332890
International Standard Serial Number (ISSN)
- 0740-3194
Digital Object Identifier (DOI)
- 10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm26>3.0.co;2-c
Language
- eng
Conference Location
- United States