In vivo MRI using real-time production of hyperpolarized 129Xe.

Journal Article (Journal Article)

MR imaging of hyperpolarized (HP) nuclei is challenging because they are typically delivered in a single dose of nonrenewable magnetization, from which the entire image must be derived. This problem can be overcome with HP (129)Xe, which can be produced sufficiently rapidly to deliver in dilute form (1%) continuously and on-demand. We demonstrate a real-time in vivo delivery of HP (129)Xe mixture to rats, a capability we now routinely use for setting frequency, transmitter gain, shimming, testing pulse sequences, scout imaging, and spectroscopy. Compared to images acquired using conventional fully concentrated (129)Xe, real-time (129)Xe images have 26-fold less signal, but clearly depict ventilation abnormalities. Real-time (129)Xe MRI could be useful for time-course studies involving acute injury or response to treatment. Ultimately, real-time (129)Xe MRI could be done with more highly concentrated (129)Xe, which could increase the signal-to-noise ratio by 100 relative to these results to enable a new class of gas imaging applications.

Full Text

Duke Authors

Cited Authors

  • Driehuys, B; Pollaro, J; Cofer, GP

Published Date

  • July 2008

Published In

Volume / Issue

  • 60 / 1

Start / End Page

  • 14 - 20

PubMed ID

  • 18581406

Pubmed Central ID

  • PMC2548276

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.21651


  • eng

Conference Location

  • United States