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Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use.

Publication ,  Journal Article
Jones, LD; Payne, ME; Messer, DF; Beyer, JL; MacFall, JR; Krishnan, KRR; Taylor, WD
Published in: J Affect Disord
April 2009

BACKGROUND: We tested for differences in temporal lobe volume in bipolar disorder and the relationship between these volumes and psychotropic medication use. METHODS: 125 subjects with bipolar disorder and 87 comparison subjects with no psychiatric illness completed clinical interviews and 1.5T MRI brain scans. Temporal lobe volumes were manually traced and segmented into gray matter and white matter volumes using an automated process. General linear models examined the relationship between these volumes and diagnosis as the primary predictor with age, sex, education, and race as copredictors. Secondary analyses incorporated the use of psychotropic medication into the linear models, and parsimonious models developed through backwards regression. RESULTS: In initial models, subjects with bipolar disorder exhibited larger temporal lobe white matter bilaterally (left: F(1,211)=2.86, p=0.0047; right: F(1,211)=3.25, p=0.0014). Current antipsychotic use was significantly associated with larger bilateral temporal lobe white matter volumes (left: F(2,211)=9.45, p=0.0001; right: F(2,211)=10.79, p<0.0001), wherein bipolar subjects taking antipsychotics had larger volumes than bipolar subjects not taking antipsychotics or healthy comparison subjects. Temporal lobe gray matter volume was not significantly associated with diagnosis or medication use. LIMITATIONS: Excluding subjects with substance use disorders may limit the study's generalizability. CONCLUSIONS: These findings indicate that differences in temporal lobe white matter are associated with bipolar disorder and use of antipsychotic medications.

Duke Scholars

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

April 2009

Volume

114

Issue

1-3

Start / End Page

50 / 57

Location

Netherlands

Related Subject Headings

  • Temporal Lobe
  • Sex Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Linear Models
  • Image Processing, Computer-Assisted
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Jones, L. D., Payne, M. E., Messer, D. F., Beyer, J. L., MacFall, J. R., Krishnan, K. R. R., & Taylor, W. D. (2009). Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use. J Affect Disord, 114(1–3), 50–57. https://doi.org/10.1016/j.jad.2008.07.003
Jones, Lindsay D., Martha E. Payne, Denise F. Messer, John L. Beyer, James R. MacFall, K Ranga R. Krishnan, and Warren D. Taylor. “Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use.J Affect Disord 114, no. 1–3 (April 2009): 50–57. https://doi.org/10.1016/j.jad.2008.07.003.
Jones LD, Payne ME, Messer DF, Beyer JL, MacFall JR, Krishnan KRR, et al. Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use. J Affect Disord. 2009 Apr;114(1–3):50–7.
Jones, Lindsay D., et al. “Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use.J Affect Disord, vol. 114, no. 1–3, Apr. 2009, pp. 50–57. Pubmed, doi:10.1016/j.jad.2008.07.003.
Jones LD, Payne ME, Messer DF, Beyer JL, MacFall JR, Krishnan KRR, Taylor WD. Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use. J Affect Disord. 2009 Apr;114(1–3):50–57.
Journal cover image

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

April 2009

Volume

114

Issue

1-3

Start / End Page

50 / 57

Location

Netherlands

Related Subject Headings

  • Temporal Lobe
  • Sex Factors
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Linear Models
  • Image Processing, Computer-Assisted
  • Humans