Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.

Journal Article (Journal Article)

OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with 16 elderly subjects who were not depressed. Diffusion tensor imaging was used to measure the fractional anisotropy of the white matter in the dorsolateral prefrontal cortex's superior and middle frontal gyri bilaterally and in the left occipital lobe as a control region. The authors compared results between groups while controlling for age, sex, and comorbid medical disorders. RESULTS: Even after controlling for age, sex, hypertension, and heart disease, the authors found significantly lower fractional anisotropy values in the right superior frontal gyrus white matter of depressed patients than comparison subjects. CONCLUSIONS: Microstructural changes in the white matter of the right superior frontal gyrus are associated with late-life depression. Further work is needed to determine how these changes contribute to depression outcomes.

Full Text

Duke Authors

Cited Authors

  • Taylor, WD; MacFall, JR; Payne, ME; McQuoid, DR; Provenzale, JM; Steffens, DC; Krishnan, KRR

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 161 / 7

Start / End Page

  • 1293 - 1296

PubMed ID

  • 15229065

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.161.7.1293


  • eng

Conference Location

  • United States