The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults.


Journal Article

We examined the relationship between COMT Val158Met genotype and temporal lobe volumes, including the caudate as a control region. Thirty-one healthy subjects completed 1.5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes.

Full Text

Duke Authors

Cited Authors

  • Taylor, WD; Züchner, S; Payne, ME; Messer, DF; Doty, TJ; MacFall, JR; Beyer, JL; Krishnan, KRR

Published Date

  • July 15, 2007

Published In

Volume / Issue

  • 155 / 2

Start / End Page

  • 173 - 177

PubMed ID

  • 17521892

Pubmed Central ID

  • 17521892

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/j.pscychresns.2007.01.005


  • eng

Conference Location

  • Ireland