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Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).

Publication ,  Journal Article
Eckstein, F; Buck, RJ; Wyman, BT; Kotyk, JJ; Le Graverand, M-PH; Remmers, AE; Evelhoch, JL; Hudelmaier, M; Charles, HC
Published in: Magn Reson Med
August 2007

MRI-based cartilage morphometry was previously validated in the absence of gadopentate dimeglumine (Gd-DTPA). However, Gd-DTPA is required for compositional (proteoglycan) imaging using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Therefore, the effect of Gd-DTPA on cartilage morphometry was studied. A total of 165 female participants (67 with and 98 without osteoarthritis [OA]) were imaged at 3.0 Tesla before and 2 hr after intravenous Gd-DTPA injection. Flip angles in post-Gd-DTPA scans varied between 12 degrees and 35 degrees . Cartilage volume and thickness of post- vs. pre-Gd-DTPA scans showed intraclass correlation coefficients (ICCs) of 0.85 > or = r > or = 0.95, mean differences between -2.1% and +1.1%, and standard deviations (SDs) of differences between 4.7% and 9.2%. Mixed-effect models found no consistent impact of flip angle and OA status on post- vs. pre-Gd-DTPA differences. Accurate morphological measurements of cartilage can be obtained after Gd-DTPA injection, allowing compositional and morphological imaging to be combined into one session.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

August 2007

Volume

58

Issue

2

Start / End Page

402 / 406

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Osteoarthritis, Knee
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Injections, Intravenous
  • Image Processing, Computer-Assisted
  • Humans
  • Gadolinium DTPA
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Eckstein, F., Buck, R. J., Wyman, B. T., Kotyk, J. J., Le Graverand, M.-P., Remmers, A. E., … Charles, H. C. (2007). Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA). Magn Reson Med, 58(2), 402–406. https://doi.org/10.1002/mrm.21290
Eckstein, Felix, Robert J. Buck, Bradley T. Wyman, John J. Kotyk, Marie-Pierre Hellio Le Graverand, Ann E. Remmers, Jeffrey L. Evelhoch, Martin Hudelmaier, and H Cecil Charles. “Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).Magn Reson Med 58, no. 2 (August 2007): 402–6. https://doi.org/10.1002/mrm.21290.
Eckstein F, Buck RJ, Wyman BT, Kotyk JJ, Le Graverand M-PH, Remmers AE, et al. Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA). Magn Reson Med. 2007 Aug;58(2):402–6.
Eckstein, Felix, et al. “Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).Magn Reson Med, vol. 58, no. 2, Aug. 2007, pp. 402–06. Pubmed, doi:10.1002/mrm.21290.
Eckstein F, Buck RJ, Wyman BT, Kotyk JJ, Le Graverand M-PH, Remmers AE, Evelhoch JL, Hudelmaier M, Charles HC. Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA). Magn Reson Med. 2007 Aug;58(2):402–406.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

August 2007

Volume

58

Issue

2

Start / End Page

402 / 406

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Osteoarthritis, Knee
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Injections, Intravenous
  • Image Processing, Computer-Assisted
  • Humans
  • Gadolinium DTPA
  • Female