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Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction.

Publication ,  Journal Article
Trimble, MA; Borges-Neto, S; Honeycutt, EF; Shaw, LK; Pagnanelli, R; Chen, J; Iskandrian, AE; Garcia, EV; Velazquez, EJ
Published in: J Nucl Cardiol
2008

BACKGROUND: Using phase analysis of gated single photon emission computed tomography (SPECT) imaging, we examined the relation between myocardial perfusion, degree of electrical dyssynchrony, and degree of SPECT-derived mechanical dyssynchrony in patients with left ventricular (LV) dysfunction. METHODS AND RESULTS: We retrospectively examined 125 patients with LV dysfunction and ejection fraction of 35% or lower. Fourier analysis converts regional myocardial counts into a continuous thickening function, allowing resolution of phase of onset of myocardial thickening. The SD of LV phase distribution (phase SD) and histogram bandwidth describe LV phase dispersion as a measure of dyssynchrony. Heart failure (HF) patients with perfusion abnormalities have higher degrees of dyssynchrony measured by median phase SD (45.5 degrees vs 27.7 degrees, P < .0001) and bandwidth (117.0 degrees vs 73.0 degrees, P = .0006). HF patients with prolonged QRS durations have higher degrees of dyssynchrony measured by median phase SD (54.1 degrees vs 34.7 degrees, P < .0001) and bandwidth (136.5 degrees vs 99.0 degrees, P = .0005). Mild to moderate correlations exist between QRS duration and phase analysis indices of phase SD (r = 0.50) and bandwidth (r = 0.40). Mechanical dyssynchrony (phase SD >43 degrees) was 43.2%. CONCLUSIONS: HF patients with perfusion abnormalities or prolonged QRS durations have higher degrees of mechanical dyssynchrony. Gated SPECT myocardial perfusion imaging can quantify myocardial function, perfusion, and dyssynchrony and may help in evaluating patients for cardiac resynchronization therapy.

Duke Scholars

Published In

J Nucl Cardiol

DOI

EISSN

1532-6551

Publication Date

2008

Volume

15

Issue

5

Start / End Page

663 / 670

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Tomography, Emission-Computed, Single-Photon
  • Retrospective Studies
  • Perfusion
  • Myocardium
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Gated Blood-Pool Imaging
 

Citation

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Trimble, M. A., Borges-Neto, S., Honeycutt, E. F., Shaw, L. K., Pagnanelli, R., Chen, J., … Velazquez, E. J. (2008). Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. J Nucl Cardiol, 15(5), 663–670. https://doi.org/10.1016/j.nuclcard.2008.06.007
Trimble, Mark A., Salvador Borges-Neto, Emily F. Honeycutt, Linda K. Shaw, Robert Pagnanelli, Ji Chen, Ami E. Iskandrian, Ernest V. Garcia, and Eric J. Velazquez. “Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction.J Nucl Cardiol 15, no. 5 (2008): 663–70. https://doi.org/10.1016/j.nuclcard.2008.06.007.
Trimble MA, Borges-Neto S, Honeycutt EF, Shaw LK, Pagnanelli R, Chen J, et al. Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. J Nucl Cardiol. 2008;15(5):663–70.
Trimble, Mark A., et al. “Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction.J Nucl Cardiol, vol. 15, no. 5, 2008, pp. 663–70. Pubmed, doi:10.1016/j.nuclcard.2008.06.007.
Trimble MA, Borges-Neto S, Honeycutt EF, Shaw LK, Pagnanelli R, Chen J, Iskandrian AE, Garcia EV, Velazquez EJ. Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. J Nucl Cardiol. 2008;15(5):663–670.
Journal cover image

Published In

J Nucl Cardiol

DOI

EISSN

1532-6551

Publication Date

2008

Volume

15

Issue

5

Start / End Page

663 / 670

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Tomography, Emission-Computed, Single-Photon
  • Retrospective Studies
  • Perfusion
  • Myocardium
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Gated Blood-Pool Imaging