Fast spectroscopic imaging strategies for potential applications in fMRI.


Journal Article

Technical aspects of two general fast spectroscopic imaging (SI) strategies, one based on gradient echo trains and the other on spin echo trains, are reviewed within the context of potential applications in the field of functional magnetic resonance imaging (fMRI). Fast spectroscopic imaging of water may prove useful for identifying mechanisms underlying the blood oxygenation level dependence (BOLD) of the water signal during brain activation studies. Reasonably rapid mapping of changes in proton signals from brain metabolites, like lactate, creatine or even neurotransmitter associated metabolites like GABA, is substantially more challenging but technically feasible particularly as higher field strengths become available. Fast spectroscopic methods directed towards the 31P signals from phosphocreatine (PCr) and adenosine tri-phosphates (ATP) are also technically feasible and may prove useful for studying cerebral energetics within fMRI contexts.

Full Text

Cited Authors

  • Mulkern, RV; Chen, N-K; Oshio, K; Panych, LP; Rybicki, FJ; Gambarota, G

Published Date

  • December 2004

Published In

Volume / Issue

  • 22 / 10

Start / End Page

  • 1395 - 1405

PubMed ID

  • 15707789

Pubmed Central ID

  • 15707789

International Standard Serial Number (ISSN)

  • 0730-725X

Digital Object Identifier (DOI)

  • 10.1016/j.mri.2004.10.011


  • eng

Conference Location

  • Netherlands