Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer.


Journal Article (Review)

Methods of optical spectroscopy that provide quantitative, physically or physiologically meaningful measures of tissue properties are an attractive tool for the study, diagnosis, prognosis, and treatment of various cancers. Recent development of methodologies to convert measured reflectance and fluorescence spectra from tissue to cancer-relevant parameters such as vascular volume, oxygenation, extracellular matrix extent, metabolic redox states, and cellular proliferation have significantly advanced the field of tissue optical spectroscopy. The number of publications reporting quantitative tissue spectroscopy results in the UV-visible wavelength range has increased sharply in the past three years, and includes new and emerging studies that correlate optically measured parameters with independent measures such as immunohistochemistry, which should aid in increased clinical acceptance of these technologies.

Full Text

Duke Authors

Cited Authors

  • Brown, JQ; Vishwanath, K; Palmer, GM; Ramanujam, N

Published Date

  • February 2009

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 119 - 131

PubMed ID

  • 19268567

Pubmed Central ID

  • 19268567

Electronic International Standard Serial Number (EISSN)

  • 1879-0429

Digital Object Identifier (DOI)

  • 10.1016/j.copbio.2009.02.004


  • eng

Conference Location

  • England