Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo.

Published

Journal Article

A hybrid optical device that uses a multimode fiber coupled to a tunable light source for illumination and a 2.4-mm photodiode for detection in contact with the tissue surface is developed as a first step toward our goal of developing a cost-effective, miniature spectral imaging device to map tissue optical properties in vivo. This device coupled with an inverse Monte Carlo model of reflectance is demonstrated to accurately quantify tissue absorption and scattering in tissue-like turbid synthetic phantoms with a wide range of optical properties. The overall errors for quantifying the absorption and scattering coefficients are 6.0+/-5.6 and 6.1+/-4.7%, respectively. Compared with fiber-based detection, having the detector right at the tissue surface can significantly improve light collection efficiency, thus reducing the requirement for sophisticated detectors with high sensitivity, and this design can be easily expanded into a quantitative spectral imaging system for mapping tissue optical properties in vivo.

Full Text

Duke Authors

Cited Authors

  • Yu, B; Lo, JY; Kuech, TF; Palmer, GM; Bender, JE; Ramanujam, N

Published Date

  • November 2008

Published In

Volume / Issue

  • 13 / 6

Start / End Page

  • 060505 -

PubMed ID

  • 19123646

Pubmed Central ID

  • 19123646

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.3041500

Language

  • eng

Conference Location

  • United States