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Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer.

Publication ,  Journal Article
Zhu, C; Palmer, GM; Breslin, TM; Xu, F; Ramanujam, N
Published in: J Biomed Opt
2005

We explore the effects of the illumination and collection geometry on optical spectroscopic diagnosis of breast cancer. Fluorescence and diffuse reflectance spectroscopy in the UV-visible spectral range are made with a multiseparation probe at three illumination-collection separations of 735, 980, and 1225 microm, respectively, from 13 malignant and 34 nonmalignant breast tissues. Statistical analysis is carried out on two types of data inputs: (1) the fluorescence and diffuse reflectance spectra recorded at each of the three illumination-collection separations and (2) the integrated fluorescence (at each excitation wavelength) or diffuse reflectance over the entire spectrum at all three illumination-collection separations. The results show that using the integrated fluorescence intensities recorded at a single excitation wavelength at all three illumination-collection separations can discriminate malignant from nonmalignant breast tissues with similar classification accuracy to that using spectral data measured at several excitation wavelengths with a single illumination-collection separation. These findings have significant implications with respect to the design of an optical system for breast cancer diagnosis. Examining the intensity attenuation at a single wavelength rather than spectral intensities at multiple wavelengths can significantly reduce the measurement and data processing time in a clinical setting as well as the cost and complexity of the optical system.

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Published In

J Biomed Opt

DOI

ISSN

1083-3668

Publication Date

2005

Volume

10

Issue

2

Start / End Page

024032

Location

United States

Related Subject Headings

  • Spectrometry, Fluorescence
  • Scattering, Radiation
  • Optics
  • Optical Fibers
  • Humans
  • Fiber Optic Technology
  • Female
  • Equipment Design
  • Breast Neoplasms
  • 5102 Atomic, molecular and optical physics
 

Citation

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Zhu, C., Palmer, G. M., Breslin, T. M., Xu, F., & Ramanujam, N. (2005). Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer. J Biomed Opt, 10(2), 024032. https://doi.org/10.1117/1.1897398
Zhu, Changfang, Gregory M. Palmer, Tara M. Breslin, Fushen Xu, and Nirmala Ramanujam. “Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer.J Biomed Opt 10, no. 2 (2005): 024032. https://doi.org/10.1117/1.1897398.
Zhu C, Palmer GM, Breslin TM, Xu F, Ramanujam N. Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer. J Biomed Opt. 2005;10(2):024032.
Zhu, Changfang, et al. “Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer.J Biomed Opt, vol. 10, no. 2, 2005, p. 024032. Pubmed, doi:10.1117/1.1897398.
Zhu C, Palmer GM, Breslin TM, Xu F, Ramanujam N. Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer. J Biomed Opt. 2005;10(2):024032.

Published In

J Biomed Opt

DOI

ISSN

1083-3668

Publication Date

2005

Volume

10

Issue

2

Start / End Page

024032

Location

United States

Related Subject Headings

  • Spectrometry, Fluorescence
  • Scattering, Radiation
  • Optics
  • Optical Fibers
  • Humans
  • Fiber Optic Technology
  • Female
  • Equipment Design
  • Breast Neoplasms
  • 5102 Atomic, molecular and optical physics