A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes.


Journal Article

A diffuse reflectance spectroscopy system was modified as a step towards miniaturization and spectral imaging of tissue absorption and scattering. The modified system uses a tunable source and an optical fiber for illumination and a photodiode in contact with tissue for detection. Compared to the previous system, it is smaller, less costly, and has comparable performance in extracting optical properties in tissue phantoms. Wavelength reduction simulations show the feasibility of replacing the source with LEDs to further decrease system size and cost. Simulated crosstalk analysis indicates that this evolving system can be multiplexed for spectral imaging in the future.

Full Text

Duke Authors

Cited Authors

  • Lo, JY; Yu, B; Fu, HL; Bender, JE; Palmer, GM; Kuech, TF; Ramanujam, N

Published Date

  • February 2, 2009

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 1372 - 1384

PubMed ID

  • 19188966

Pubmed Central ID

  • 19188966

Electronic International Standard Serial Number (EISSN)

  • 1094-4087

Digital Object Identifier (DOI)

  • 10.1364/oe.17.001372


  • eng

Conference Location

  • United States