Skip to main content

Mitomycin-induced hemolytic-uremic syndrome.

Publication ,  Journal Article
Proia, AD; Harden, EA; Silberman, HR
Published in: Arch Pathol Lab Med
December 1984

Four patients who took the antitumor agent mitomycin manifested microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. At autopsy, kidneys from all four patients had a microangiopathy typical of the hemolytic-uremic syndrome (HUS), with thromboses in glomerular capillaries and arterioles, fibrin deposition in mesangium, and prominent cellular intimal proliferation of the interlobular arteries. Development of the HUS was an important factor contributing to death in all four patients. From a review of the literature and our initial results of a randomized chemotherapy protocol for metastatic adenocarcinoma of the colorectum, it appears that mitomycin was the most likely cause for the development of the HUS in these patients. As more patients are being treated with mitomycin, particular care must be taken to monitor them for development of a drug-induced HUS.

Duke Scholars

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

December 1984

Volume

108

Issue

12

Start / End Page

959 / 962

Location

United States

Related Subject Headings

  • Staining and Labeling
  • Pathology
  • Mitomycins
  • Male
  • Kidney Glomerulus
  • Kidney
  • Humans
  • Hemolytic-Uremic Syndrome
  • Glomerular Mesangium
  • Fibrin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Proia, A. D., Harden, E. A., & Silberman, H. R. (1984). Mitomycin-induced hemolytic-uremic syndrome. Arch Pathol Lab Med, 108(12), 959–962.
Proia, A. D., E. A. Harden, and H. R. Silberman. “Mitomycin-induced hemolytic-uremic syndrome.Arch Pathol Lab Med 108, no. 12 (December 1984): 959–62.
Proia AD, Harden EA, Silberman HR. Mitomycin-induced hemolytic-uremic syndrome. Arch Pathol Lab Med. 1984 Dec;108(12):959–62.
Proia, A. D., et al. “Mitomycin-induced hemolytic-uremic syndrome.Arch Pathol Lab Med, vol. 108, no. 12, Dec. 1984, pp. 959–62.
Proia AD, Harden EA, Silberman HR. Mitomycin-induced hemolytic-uremic syndrome. Arch Pathol Lab Med. 1984 Dec;108(12):959–962.

Published In

Arch Pathol Lab Med

ISSN

0003-9985

Publication Date

December 1984

Volume

108

Issue

12

Start / End Page

959 / 962

Location

United States

Related Subject Headings

  • Staining and Labeling
  • Pathology
  • Mitomycins
  • Male
  • Kidney Glomerulus
  • Kidney
  • Humans
  • Hemolytic-Uremic Syndrome
  • Glomerular Mesangium
  • Fibrin