Ocular cicatricial pemphigoid with granular IgA and complement deposition.

Journal Article (Journal Article)

A 65-year-old woman developed chronic redness of both eyes, and, over the ensuing 2 1/2 years, she had progressive conjunctival scarring with symblepharon formation. Other mucosal surfaces were not involved. A conjunctival biopsy specimen 12 months following onset of her disease showed areas of epithelial separation from the basement membrane zone as well as subepithelial chronic inflammation and scarring. Two years later, another conjunctival biopsy specimen showed granular deposition of IgA and C3 along the epithelial basement membrane zone using direct immunofluorescent staining. Electron microscopy confirmed the presence of deposits that were morphologically consistent with antigen-antibody complexes. These findings suggest that antigen-antibody (IgA) immune-complex deposition may provide an alternative pathogenetic mechanism to basement membrane zone autoantibody formation for development of progressive conjunctival scarring.

Full Text

Duke Authors

Cited Authors

  • Proia, AD; Foulks, GN; Sanfilippo, FP

Published Date

  • November 1985

Published In

Volume / Issue

  • 103 / 11

Start / End Page

  • 1669 - 1672

PubMed ID

  • 3904684

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.1985.01050110063026


  • eng

Conference Location

  • United States