Retinal toxicity of cyanoacrylate tissue adhesive in the rabbit.

Journal Article (Journal Article)

N-butyl-2-cyanoacrylate tissue adhesive was injected into the preretinal space of rabbit eyes to study potential toxicity to the retina. Application of 3.3-10.0 ul of cyanoacrylate tissue adhesive showed localized but definite retinal toxicity. White halos appeared surrounding the preretinal cyanoacrylate immediately after injection with a gradual evolution of the white areas into pigmentary scars by 1 month. Histological examination confirmed severe focal necrosis of the retina. No identifiable distant toxic effects or electrophysiologic changes were observed during the 6-month follow-up period.

Full Text

Duke Authors

Cited Authors

  • Hida, T; Sheta, SM; Proia, AD; McCuen, BW

Published Date

  • 1988

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 148 - 153

PubMed ID

  • 3420314

International Standard Serial Number (ISSN)

  • 0275-004X

Digital Object Identifier (DOI)

  • 10.1097/00006982-198808020-00013


  • eng

Conference Location

  • United States