Cytomegalovirus keratitis after penetrating keratoplasty.

Journal Article (Journal Article)

We report the development of cytomegalovirus (CMV) keratitis in the penetrating keratoplasty of a 59-year-old human immunodeficiency virus-negative woman after uncomplicated corneal transplantation. Immunosuppression with topical cyclosporine A 2% in corn oil and topical prednisolone acetate 1% suspension was used postoperatively. The 15-month postoperative course was complicated by multiple episodes of endothelial rejection, medically controlled elevated intraocular pressure, polymicrobial bacterial (coagulase-negative staphlococcus and alpha-hemolytic streptococcus) keratitis, and endothelial plaque formation with associated hypopyon and epithelial defect. The graft failed and penetrating keratoplasty was repeated. Cytomegalovirus infection of superficial keratocytes in a region of scarring was identified in histological sections stained with hematoxylin and eosin and confirmed using mouse monoclonal anti-cytomegalovirus antibodies. Excision of the diseased corneal button with no additional treatment appears to have been curative. Low-grade keratitis was the only manifestation of the CMV infection, and it has not recurred 6 months postoperatively.

Full Text

Duke Authors

Cited Authors

  • Wehrly, SR; Manning, FJ; Proia, AD; Burchette, JL; Foulks, GN

Published Date

  • November 1995

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 628 - 633

PubMed ID

  • 8575188

International Standard Serial Number (ISSN)

  • 0277-3740


  • eng

Conference Location

  • United States